DPP9

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DPP9
Identifiers
Aliases DPP9, DP9, DPLP9, DPRP-2, DPRP2, dipeptidyl peptidase 9
External IDs MGI: 2443967 HomoloGene: 16385 GeneCards: DPP9
Genetically Related Diseases
interstitial lung disease[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139159

NM_172624

RefSeq (protein)

NP_631898

NP_766212.2
NP_766212

Location (UCSC) Chr 19: 4.68 – 4.72 Mb Chr 17: 56.19 – 56.22 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene.[4]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.[4]

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