DPP9

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DPP9
Identifiers
AliasesDPP9, DP9, DPLP9, DPRP-2, DPRP2, dipeptidyl peptidase 9, DPP IX
External IDsMGI: 2443967 HomoloGene: 16385 GeneCards: DPP9
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for DPP9
Genomic location for DPP9
Band19p13.3Start4,675,224 bp[1]
End4,724,673 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139159
NM_001365987

NM_172624
NM_001360284

RefSeq (protein)

NP_631898
NP_001352916

NP_766212
NP_001347213

Location (UCSC)Chr 19: 4.68 – 4.72 MbChr 17: 56.19 – 56.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene.[5]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142002 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001229 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: DPP9 dipeptidyl-peptidase 9".

Further reading[edit]