DPYS

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DPYS
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DPYS, dihydropyrimidinase, DHP, DHPase
External IDs MGI: 1928679 HomoloGene: 20359 GeneCards: 1807
RNA expression pattern
PBB GE DPYS 206065 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001385

NM_001164466
NM_022722

RefSeq (protein)

NP_001376.1

NP_001157938.1
NP_073559.3

Location (UCSC) Chr 8: 104.33 – 104.47 Mb Chr 15: 39.77 – 39.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.[1][2]

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1-2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361. 
  2. ^ a b "Entrez Gene: DPYS dihydropyrimidinase". 

Further reading[edit]