Prostaglandin D2 receptor

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Prostaglandin D2 receptor (DP)
Symbols PTGDR ; AS1; ASRT1; DP; DP1; PTGDR1
External IDs OMIM604687 MGI102966 HomoloGene736 IUPHAR: 338 ChEMBL: 4427 GeneCards: PTGDR Gene
RNA expression pattern
PBB GE PTGDR 215894 at tn.png
More reference expression data
Species Human Mouse
Entrez 5729 19214
Ensembl ENSG00000168229 ENSMUSG00000071489
UniProt Q13258 P70263
RefSeq (mRNA) NM_000953 NM_008962
RefSeq (protein) NP_000944 NP_032988
Location (UCSC) Chr 14:
52.27 – 52.28 Mb
Chr 14:
44.85 – 44.86 Mb
PubMed search [1] [2]

Prostaglandin D2 receptor (DP1) is a G-protein coupled receptor, encoded by the PTGDR gene, for prostaglandin D2.[1]


DP1 is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.


Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation

See also[edit]


External links[edit]

  • "Prostanoid Receptors: DP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.