DR-4485

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DR-4485
DR-4485 structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC26H28Cl2N2O
Molar mass455.418 g/mol g·mol−1
3D model (JSmol)

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.[1][2]

References[edit]

  1. ^ Kikuchi C, Suzuki H, Hiranuma T, Koyama M. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorganic & Medicinal Chemistry Letters. 2003 Jan 6;13(1):61-4. PMID 12467617
  2. ^ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2384-92. DOI 10.1021/jm8014553. PMID 19326916