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Desmocollin 1
Symbols DSC1 ; CDHF1; DG2/DG3
External IDs OMIM125643 MGI109173 HomoloGene22761 GeneCards: DSC1 Gene
RNA expression pattern
PBB GE DSC1 207324 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1823 13505
Ensembl ENSG00000134765 ENSMUSG00000044322
UniProt Q08554 P55849
RefSeq (mRNA) NM_004948 NM_001291804
RefSeq (protein) NP_004939 NP_001278733
Location (UCSC) Chr 18:
31.13 – 31.16 Mb
Chr 18:
20.08 – 20.11 Mb
PubMed search [1] [2]

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[1][2]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[2]


DSC1 has been shown to interact with Desmoglein 2.[3]


  1. ^ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR; et al. (Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol 121 (3): 481–3. doi:10.1083/jcb.121.3.481. PMC 2119574. PMID 8486729. 
  2. ^ a b "Entrez Gene: DSC1 desmocollin 1". 
  3. ^ Chitaev, N A; Troyanovsky S M (Jul 1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion". J. Cell Biol. (UNITED STATES) 138 (1): 193–201. doi:10.1083/jcb.138.1.193. ISSN 0021-9525. PMC 2139935. PMID 9214392. 

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