DSC1

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DSC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDSC1, CDHF1, DG2/DG3, desmocollin 1
External IDsMGI: 109173 HomoloGene: 22761 GeneCards: DSC1
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for DSC1
Genomic location for DSC1
Band18q12.1Start31,129,236 bp[1]
End31,162,856 bp[1]
RNA expression pattern
PBB GE DSC1 207324 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024421
NM_004948

NM_001291804
NM_013504

RefSeq (protein)

NP_004939
NP_077739

NP_001278733
NP_038532

Location (UCSC)Chr 18: 31.13 – 31.16 MbChr 18: 20.08 – 20.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.[5][6]

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.[6]

Interactions[edit]

DSC1 has been shown to interact with Desmoglein 2.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134765 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044322 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol. 121 (3): 481–3. doi:10.1083/jcb.121.3.481. PMC 2119574. PMID 8486729.
  6. ^ a b "Entrez Gene: DSC1 desmocollin 1".
  7. ^ Chitaev, N A; Troyanovsky S M (Jul 1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion". J. Cell Biol. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. ISSN 0021-9525. PMC 2139935. PMID 9214392.

Further reading[edit]