DSE (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DSE
Identifiers
Aliases DSE, DSEP, DSEPI, EDSMC2, SART-2, SART2, DS-epi1, dermatan sulfate epimerase
External IDs MGI: 2443455 HomoloGene: 8354 GeneCards: DSE
RNA expression pattern
PBB GE DSE 218854 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_172508

RefSeq (protein)

NP_766096.1
NP_766096

Location (UCSC) Chr 6: 116.25 – 116.44 Mb Chr 10: 34.15 – 34.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.[3][4][5][6][7]

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. 
  4. ^ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484. 
  5. ^ a b "Entrez Gene: DSE dermatan sulfate epimerase". 
  6. ^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. 
  7. ^ Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484. 

Further reading[edit]