DSN1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DSN1
Identifiers
Aliases DSN1, C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3, DSN1 homolog, MIS12 kinetochore complex component
External IDs MGI: 1914184 HomoloGene: 49806 GeneCards: DSN1
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DSN1
Genomic location for DSN1
Band 20q11.23 Start 36,751,791 bp[1]
End 36,773,818 bp[1]
RNA expression pattern
PBB GE DSN1 219512 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145315
NM_001145316
NM_001145317
NM_001145318
NM_024918

NM_025853

RefSeq (protein)

NP_001138787
NP_001138788
NP_001138789
NP_001138790
NP_079194

NP_080129

Location (UCSC) Chr 20: 36.75 – 36.77 Mb Chr 20: 157 – 157.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.[5][6]

Function[edit]

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis.[6][7]

Interactions[edit]

DSN1 has been shown to interact with NSL1[8] and MIS12.[6][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149636 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027635 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)". 
  6. ^ a b c Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. 
  7. ^ Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, McGlothen T, Peng W, You T, Sun M, Cui T, Hu R, Dou Z, Zhu J, Xie W, Rao Z, Ding X, Yao X (September 2008). "Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): 26726–36. doi:10.1074/jbc.M804207200. PMC 2546542Freely accessible. PMID 18640974. 
  8. ^ Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. 
  9. ^ Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519Freely accessible. PMID 15371340. 

Further reading[edit]