DTNB

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This article is about the DTNB gene and protein. For the chemical substance, see Ellman's reagent.
DTNB
Identifiers
Aliases DTNB
External IDs MGI: 1203728 HomoloGene: 74875 GeneCards: DTNB
Genetically Related Diseases
multiple myeloma, coronary artery disease[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001162465
NM_007886

RefSeq (protein)

NP_001155937.1
NP_001155937
NP_031912

Location (UCSC) Chr 2: 25.38 – 25.67 Mb Chr 12: 3.57 – 3.78 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.[4]

Function[edit]

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.