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This article is about the DTNB gene and protein. For the chemical substance, see Ellman's reagent.
Dystrobrevin, beta
Symbols DTNB ; MGC17163; MGC57126
External IDs OMIM602415 MGI1203728 HomoloGene74875 GeneCards: DTNB Gene
Species Human Mouse
Entrez 1838 13528
Ensembl ENSG00000138101 ENSMUSG00000071454
UniProt O60941 O70585
RefSeq (mRNA) NM_001256303 NM_001162465
RefSeq (protein) NP_001243232 NP_001155937
Location (UCSC) Chr 2:
25.38 – 25.67 Mb
Chr 12:
3.57 – 3.78 Mb
PubMed search [1] [2]

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.[1]


This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


  1. ^ Blake DJ, Nawrotzki R, Loh NY, Górecki DC, Davies KE (January 1998). "beta-dystrobrevin, a member of the dystrophin-related protein family". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 241–6. doi:10.1073/pnas.95.1.241. PMC 18188. PMID 9419360. 
  2. ^ "Entrez Gene: DTNB dystrobrevin, beta". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.