From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases DUSP12, DUSP1, YVH1, dual specificity phosphatase 12
External IDs MGI: 1890614 HomoloGene: 5238 GeneCards: DUSP12
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DUSP12
Genomic location for DUSP12
Band 1q23.3 Start 161,749,758 bp[1]
End 161,757,238 bp[1]
RNA expression pattern
PBB GE DUSP12 218576 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 161.75 – 161.76 Mb Chr 1: 170.87 – 170.89 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.[5][6]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081721 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026659 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Muda M, Manning ER, Orth K, Dixon JE (Sep 1999). "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem. 274 (34): 23991–5. doi:10.1074/jbc.274.34.23991. PMID 10446167. 
  6. ^ a b "Entrez Gene: DUSP12 dual specificity phosphatase 12". 

Further reading[edit]