DUSP13

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DUSP13
Protein DUSP13 PDB 2gwo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DUSP13, BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity phosphatase 13
External IDs MGI: 1351599 HomoloGene: 121602 GeneCards: DUSP13
RNA expression pattern
PBB GE DUSP13 219963 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007268
NM_013849

RefSeq (protein)

NP_001007269.1
NP_038877.2

Location (UCSC) Chr 10: 75.09 – 75.11 Mb Chr 14: 21.73 – 21.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.[3]

Function[edit]

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.[3]

References[edit]

Further reading[edit]