DUSP16

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DUSP16
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases DUSP16, MKP-7, MKP7, dual specificity phosphatase 16
External IDs MGI: 1917936 HomoloGene: 15604 GeneCards: DUSP16
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030640

NM_001048054
NM_130447
NM_181320

RefSeq (protein)

NP_085143
NP_085143.1

n/a

Location (UCSC) Chr 12: 12.47 – 12.56 Mb Chr 6: 134.72 – 134.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[3][4][5][6]

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][6]

Interactions[edit]

DUSP16 has been shown to interact with MAPK14[7][8] and MAPK8IP1.[9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773. 
  4. ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. PMID 11489891. 
  5. ^ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem. 280 (27): 25651–8. doi:10.1074/jbc.M501926200. PMID 15888437. 
  6. ^ a b "Entrez Gene: DUSP16 dual specificity phosphatase 16". 
  7. ^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773. 
  8. ^ Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. United States. 276 (42): 39002–11. doi:10.1074/jbc.M104600200. ISSN 0021-9258. PMID 11489891. 
  9. ^ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. United States. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447. 

Further reading[edit]