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Dual specificity phosphatase 22
PBB Protein DUSP22 image.jpg
PDB rendering based on 1wrm.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs MGI1915926 HomoloGene86039 ChEMBL: 3924 GeneCards: DUSP22 Gene
EC number,
RNA expression pattern
PBB GE DUSP22 218845 at tn.png
More reference expression data
Species Human Mouse
Entrez 56940 105352
Ensembl ENSG00000112679 ENSMUSG00000069255
UniProt Q9NRW4 Q99N11
RefSeq (mRNA) NM_020185 NM_001037955
RefSeq (protein) NP_064570 NP_001033044
Location (UCSC) Chr 6:
0.29 – 0.35 Mb
Chr 13:
30.66 – 30.71 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.[1][2][3]


DUSP22 has been shown to interact with MAPK1[4] and MAPK8.[4]


  1. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128. 
  2. ^ Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (Nov 2001). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1". Proc Natl Acad Sci U S A 98 (24): 13613–8. doi:10.1073/pnas.231499098. PMC 61089. PMID 11717427. 
  3. ^ "Entrez Gene: DUSP22 dual specificity phosphatase 22". 
  4. ^ a b Aoyama, K; Nagata M; Oshima K; Matsuda T; Aoki N (Jul 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. (United States) 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMID 11346645. 

Further reading[edit]