DUSP4

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MKP 2, homo24mer, Human.
DUSP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDUSP4, HVH2, MKP-2, MKP2, TYP, dual specificity phosphatase 4
External IDsOMIM: 602747 MGI: 2442191 HomoloGene: 1065 GeneCards: DUSP4
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DUSP4
Genomic location for DUSP4
Band8p12Start29,333,064 bp[1]
End29,350,684 bp[1]
RNA expression pattern
PBB GE DUSP4 204014 at fs.png

PBB GE DUSP4 204015 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001394
NM_057158

NM_176933

RefSeq (protein)

NP_001385
NP_476499

NP_795907

Location (UCSC)Chr 8: 29.33 – 29.35 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.[4][5][6]

Function[edit]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.[6]

In melanocytic cells DUSP4 gene expression may be regulated by MITF.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120875 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Guan KL, Butch E (Mar 1995). "Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase". The Journal of Biological Chemistry. 270 (13): 7197–203. doi:10.1074/jbc.270.13.7197. PMID 7535768.
  5. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Jun 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
  6. ^ a b "Entrez Gene: DUSP4 dual specificity phosphatase 4".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading[edit]

External links[edit]

  • Overview of all the structural information available in the PDB for UniProt: Q13115 (Human Dual specificity protein phosphatase 4) at the PDBe-KB.