DVL2

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DVL2
Protein DVL2 PDB 1l6o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DVL2
External IDs MGI: 106613 HomoloGene: 20927 GeneCards: 1856
RNA expression pattern
PBB GE DVL2 218759 at tn.png

PBB GE DVL2 57532 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004422

NM_007888

RefSeq (protein)

NP_004413.1

NP_031914.3

Location (UCSC) Chr 17: 7.23 – 7.23 Mb Chr 11: 70 – 70.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[1][2]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[2]

Interactions[edit]

DVL2 has been shown to interact with Zinc finger protein 165,[3] DAB2[4] and Arrestin beta 1.[5]

See also[edit]

References[edit]

  1. ^ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. 
  2. ^ a b "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)". 
  3. ^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. 
  5. ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073. 

Further reading[edit]