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Protein DVL2 PDB 1l6o.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases DVL2, dishevelled segment polarity protein 2
External IDs MGI: 106613 HomoloGene: 20927 GeneCards: DVL2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for DVL2
Genomic location for DVL2
Band 17p13.1 Start 7,225,341 bp[1]
End 7,234,545 bp[1]
RNA expression pattern
PBB GE DVL2 57532 at fs.png

PBB GE DVL2 218759 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 7.23 – 7.23 Mb Chr 17: 70 – 70.01 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[5][6]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[6]


DVL2 has been shown to interact with Zinc finger protein 165,[7] DAB2[8] and Arrestin beta 1.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004975 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020888 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. 
  6. ^ a b "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)". 
  7. ^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138Freely accessible. PMID 12805222. 
  9. ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. United States. 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954Freely accessible. PMID 11742073. 

Further reading[edit]