DVL3

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DVL3
Protein DVL3 PDB 1l6o.png
Identifiers
Aliases DVL3, DRS3, dishevelled segment polarity protein 3
External IDs MGI: 108100 HomoloGene: 20928 GeneCards: DVL3
RNA expression pattern
PBB GE DVL3 201908 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004423

NM_007889
NM_001347176

RefSeq (protein)

NP_004414

NP_031915.2
NP_001334105
NP_031915

Location (UCSC) Chr 3: 184.16 – 184.17 Mb Chr 16: 20.52 – 20.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.[3][4]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[4]

Interactions[edit]

DVL3 has been shown to interact with DAB2,[5] DVL1[6] and PRPF3.[7]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329. 
  4. ^ a b "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)". 
  5. ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138Freely accessible. PMID 12805222. 
  6. ^ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. UNITED STATES. 19 (6): 4414–22. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400Freely accessible. PMID 10330181. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]