DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).
It is classified under EC 188.8.131.527.
It is part of the nonmevalonate pathway (MEP pathway), and it is inhibited by fosmidomycin.
It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.
This enzyme is responsible for terpenoid biosynthesis in some organisms. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.
This article incorporates text from the public domain Pfam and InterPro IPR013512 This article incorporates text from the public domain Pfam and InterPro IPR013644