From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dynein, cytoplasmic 1, intermediate chain 1
Symbols DYNC1I1 ; DNCI1; DNCIC1
External IDs OMIM603772 MGI107743 HomoloGene68398 GeneCards: DYNC1I1 Gene
RNA expression pattern
PBB GE DYNC1I1 205348 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1780 13426
Ensembl ENSG00000158560 ENSMUSG00000029757
UniProt O14576 O88485
RefSeq (mRNA) NM_001135556 NM_001191023
RefSeq (protein) NP_001129028 NP_001177952
Location (UCSC) Chr 7:
95.77 – 96.11 Mb
Chr 6:
5.73 – 6.03 Mb
PubMed search [1] [2]

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.[1][2][3]

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.[4]


DYNC1I1 has been shown to interact with DYNLL1.[5]


  1. ^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579. 
  2. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. 
  3. ^ "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry (United States) 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239. 

Further reading[edit]