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Dynein, light chain, LC8-type 2
Protein DYNLL2 PDB 1cmi.png
PDB rendering based on 1cmi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DYNLL2 ; DNCL1B; Dlc2; RSPH22
External IDs OMIM608942 MGI1915347 HomoloGene115597 GeneCards: DYNLL2 Gene
RNA expression pattern
PBB GE DYNLL2 gnf1h10414 at tn.png
More reference expression data
Species Human Mouse
Entrez 140735 68097
Ensembl ENSG00000264364 ENSMUSG00000020483
UniProt Q96FJ2 Q9D0M5
RefSeq (mRNA) NM_080677 NM_001168471
RefSeq (protein) NP_542408 NP_001161943
Location (UCSC) Chr 17:
58.08 – 58.1 Mb
Chr 11:
87.98 – 87.99 Mb
PubMed search [1] [2]

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.[1][2]


DYNLL2 has been shown to interact with DLG4,[3] C12orf40,[4] DLGAP1,[3] MYO5A[3][5] and BMF.[5][6]


  1. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. 
  2. ^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2". 
  3. ^ a b c Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. (UNITED STATES) 20 (12): 4524–34. ISSN 0270-6474. PMID 10844022. 
  4. ^ Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. 
  5. ^ a b Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science (United States) 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. 
  6. ^ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217. 

Further reading[edit]

DYNLL2 associations with risk for generalized anxiety disorder: Donner et al. An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders. Biological Psychiatry, 2008; 64 (8): 672 doi:10.1016/j.biopsych.2008.06.002