DYNLRB1

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DYNLRB1
Protein DYNLRB1 PDB 1y4o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDs MGI: 1914318 HomoloGene: 69161 GeneCards: DYNLRB1
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DYNLRB1
Genomic location for DYNLRB1
Band 20q11.22 Start 34,516,409 bp[1]
End 34,540,958 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291108
NM_025947

RefSeq (protein)

NP_001278037
NP_080223

Location (UCSC) Chr 20: 34.52 – 34.54 Mb Chr 20: 155.24 – 155.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[5][6][7]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125971 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047459 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132. 
  6. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247Freely accessible. PMID 16260502. 
  7. ^ a b "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1". 

Further reading[edit]