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Dynein, light chain, roadblock-type 1
Protein DYNLRB1 PDB 1y4o.png
PDB rendering based on 1y4o.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607167 MGI1914318 HomoloGene69161 GeneCards: DYNLRB1 Gene
Species Human Mouse
Entrez 83658 67068
Ensembl ENSG00000125971 ENSMUSG00000047459
UniProt Q9NP97 P62627
RefSeq (mRNA) NM_001281727 NM_001291108
RefSeq (protein) NP_001268656 NP_001278037
Location (UCSC) Chr 20:
34.52 – 34.54 Mb
Chr 2:
155.24 – 155.25 Mb
PubMed search [1] [2]

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[1][2][3]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[3]


  1. ^ Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132. 
  2. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. 
  3. ^ a b "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1". 

Further reading[edit]