DYRK2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DYRK2
Protein DYRK2 PDB 3K2L.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
External IDs MGI: 1330301 HomoloGene: 48437 GeneCards: DYRK2
RNA expression pattern
PBB GE DYRK2 202968 s at fs.png

PBB GE DYRK2 202971 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006482
NM_003583

NM_001014390

RefSeq (protein)

NP_003574
NP_006473

NP_001014412.1
NP_001014412

Location (UCSC) Chr 12: 67.65 – 67.67 Mb Chr 10: 118.86 – 118.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme that in humans is encoded by the DYRK2 gene.[3][4]

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265. 
  4. ^ a b "Entrez Gene: DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2". 

Further reading[edit]