Drndić obtained a master's degree in theatre and communications from Southern Illinois University in the United States, which she attended with the aid of a Fulbright scholarship. She studied at Case Western Reserve University. In the early 1990s, she moved from Belgrade to Rijeka, and obtained her doctorate at the University of Rijeka, where she later taught. She worked for many years in the drama department of Radio Belgrade, writing and producing numerous radio plays during that time. She also worked in publishing.
The author of a number of books, Drndić is best known for her award-winning novel Sonnenschein (2007) which has been translated in many languages. It appeared in English translation under the title Trieste; the translator was Ellen Elias-Bursać. It was nominated for the Independent Foreign Fiction Prize. An earlier novel, Leica Format, was translated by Celia Hawkesworth. . In 2017, her penultimate novel, Belladonna, was published in English by New Directions Publishing (also translated by Hawkesworth).
- Put do subote (Way to Saturday), 1982
- Kamen s neba (Stone from heaven), 1984
- Marija Częstohowska još uvijek roni suze ili Umiranje u Torontu (Maria Częstohowska still shedding tears or Dying in Toronto), 1997
- Canzone di guerra, 1998
- Totenwande, 2000
- Doppelgänger, 2002
- Leica format, 2003
- Sonnenschein, 2007 (Trieste)
- April u Berlinu (April in Berlin), 2009
- Belladonna, 2012
- EEG, 2016
- Profile, fraktura.hr; accessed 6 June 2018.(in Croatian)
- "ODLAZAK DAŠE DRNDIĆ Bila je intelektualka koja nije marila za visoke tiraže. Čitatelje je izazivala, a kritičari su je obožavali..." Jutarnji list (in Croatian). 6 June 2018. Retrieved 23 October 2018.
- "Celia Hawkesworth profile". Retrieved 15 September 2017.
- Flood, Alison (6 June 2018). "Daša Drndić, 'unflinching' Croatian novelist, dies aged 71". the Guardian.
- Komunikacije, Neomedia. "ODLAZAK VELIKE KNJIŽEVNICE U Rijeci preminula Daša Drndić / Novi list". www.novilist.hr.