Dachshund (gene)

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dachshund is a gene involved in the development of the arthropod compound eye[1] which also plays a role in leg development.[2] In Drosophila, dachshund (dac) is a gene needed for embryonic leg development. It is activated by the Distal-less (Dll) gene.[3] Dachshund homologue (DACH1) regulates tumorigenesis in humans as a part of the Retinal Determination Gene Network (RDGN) complex, with cancer patients showing altered DACH1 expression.[4]

References[edit]

  1. ^ Mardon, G.; Solomon, N.M., N. M.; Rubin, G. M., G. M. (Dec 1994). "dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila". Development. 120 (12): 3473–3486. ISSN 0950-1991. PMID 7821215. 
  2. ^ Gehring, W. J.; Ikeo, K. (1999). "Pax 6: mastering eye morphogenesis and eye evolution". Trends in genetics : TIG. 15 (9): 371–377. doi:10.1016/S0168-9525(99)01776-X. PMID 10461206. 
  3. ^ Estella, Carlos; Voutev, Roumen; Mann, Richard S. (2012-01-01). "A Dynamic Network of Morphogens and Transcription Factors Patterns the Fly Leg". Current topics in developmental biology. 98: 173–198. doi:10.1016/B978-0-12-386499-4.00007-0. ISSN 0070-2153. PMC 3918458Freely accessible. PMID 22305163. 
  4. ^ Popov, Vladimir M.; Wu, Kongming; Zhou, Jie; Powell, Michael J.; Mardon, Graeme; Wang, Chenguang; Pestell, Richard G. (2010-01-01). "The Dachshund gene in development and hormone-responsive tumorigenesis". Trends in Endocrinology & Metabolism. 21 (1): 41–49. doi:10.1016/j.tem.2009.08.002. ISSN 1043-2760. PMC 2818438Freely accessible. PMID 19896866.