Bible began his coaching career at Brandon Prep School in Shelbyville, Tennessee. Mississippi College recruited him to coach in 1912, and he was recruited to coach for Texas A&M University in 1916.
In his college football coaching career, Bible compiled a record of 198–72–23. His teams had winning records in thirty of the thirty-three seasons he coached. Bible twice won ten games in a season. Bible also coached baseball and basketball at Texas A&M. During his hiatus from Texas A&M in 1918, Bible served as pilot in World War I.
Bible was the son of Jonathan David Bible (October 9, 1863 in Cocke County, Tennessee – November 23, 1942) and Cleopatra I. Willis (October 19, 1870 – January 25, 1954). The couple married on June 20, 1889. Jonathan was a college professor at Carson–Newman College in Jefferson City, Tennessee, he could quote biblical scripture and was a Greek and Latin scholar.
Bible married Rowena Rhodes on December 19, 1923. They had two children, William and Barbara. Rowena died in 1942. Dana later married Agnes Stacy in 1944 and they were divorced in 1950. He married Dorothy Gilstrap on February 2, 1952.