Giansiracusa was selected by the Bulldogs in the 1999 AFL Draft with pick 32. He made his senior debut in Round 11, 2001 against Adelaide at Football Park, and joined a special group of players when he goaled with his first kick.
After an exciting start to 2005 he missed 6 weeks due to injury but returned and ended up kicking 23 goals for the year. He had an outstanding game in round 18 against the Brisbane Lions collecting 27 possessions and kicking 2 goals.
Giansiracusa injured an anterior cruciate ligament (ACL) over the 2007–2008 off-season. The injury was not serious and he recovered in time for the 2008 season opener against Adelaide.
Giansiracusa continued to display fine form in 2011, despite the team's poor season overall. He kicked 45 goals in 20 games playing mainly as a small forward, finishing second on the goalkicking list behind Barry Hall and seventh in the club's Best and Fairest Award count. He reached a personal milestone in Round 10 when he played his 200th game for the Bulldogs.
Providing an experienced head in the Western Bulldogs forward line, Giansiracusa’s reliability around goals was imperative in 2012. In the 17 games he goaled on all but one occasion, while contributing multiple majors on eight occasions. He finished the year as the Club’s leading goal scorer.
In Round 6, 2006, against St Kilda, midway during the third quarter the Western Bulldogs were heading downfield when Giansiracusa clashed heads with Justin Koschitzke, resulting in both players lying motionless for several minutes. Giansiracusa managed to get up but Koschitzke could not. Despite the severity of the incident, the AFL Tribunal decided Giansiracusa had no case to answer for this bump.
Giansiracusa attended Altona Meadows Primary School and Emmanuel College. He married his longtime partner, Kelly Tisdale, in December 2007. The couple currently have two children: daughter Ruby Iris (born in November 2008), and son Otis.