He is best known for writing and singing on such songs as "Flirtin' with Disaster" and "Whiskey Man." He was also the vocalist on "Dreams I'll Never See," a faster-tempoed cover of the Allman Brothers song. The band's sound was immediately recognizable by Brown's distinct voice: a deep, raspy, throaty growl.
Brown left Molly Hatchet in 1980 because of chronic diabetes and pancreatic problems, but soon started his own band, The Danny Joe Brown Band, which released a single studio album in 1981. He later rejoined Molly Hatchet in 1982, only to leave again in 1995 after suffering a stroke. He died at his mother's home in Davie, Florida in March 2005, at the age of 53. His obituary attributed his death to renal failure, a complication of the diabetes he had since age 19.