He is considered one of the great contemporary steel framebuilders and a pioneer of lugless TIG welded frames. Pegoretti uses only steel and aluminum to create his frames, having used tubes from Excel, Dedacciai, and most recently Columbus. His current models include the Responsorium, Day is Done, Big Leg Emma, Mxxxxxo, Duende, Luigino, Love #3, and 8:30.
Pegoretti has also created custom paint and graphics designs for customers. The 'ciavate' paint scheme is entirely hand-painted by Dario and originally drew inspiration from Jean-Michel Basquiat.
Pegoretti designed and built frames that were ridden by Miguel Indurain, Marco Pantani, Stephen Roche, Claudio Chiappucci, Mario Cipollini, and Andrea Tafi among others. He started out as a contract builder, making frames that would be labeled by other manufacturers until the American distributor Gita convinced him to build under his own name. Floyd Landis owns and rides a Love #3. He supplied comedian Robin Williams with bikes that the actor regularly used and particularly admired; and Williams also gave them as gifts.
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- Gay, Jason (August 14, 2014). "Robin Williams and Dario Pegoretti: The Comedian and the Bike Builder". Wall Street Journal. Retrieved August 18, 2014.
- McMahon, Daniel (August 25, 2014). "The Beloved Bike Robin Williams Donated Just Weeks Before He Died Raised $20,000 For Charity". Business Insider. Retrieved December 30, 2014.
- Taunber, Michell (August 24, 2014). "Robin Williams's Widow Is 'Surprisingly Resilient,' Says Friend". People Magazine. Retrieved December 30, 2014.
- "Hand Made Bicycle Show" (PDF). North American Handmade Bicycle Show. 2014. Retrieved 15 March 2015.
- Huang, James, Ed.; Verkuylen, Paul (February 15, 2008). "Pegoretti named frame builder of the year". Cycling News. www.cyclingnews.com. Retrieved August 18, 2014.