He was the thirteenth and last child of Samuel Clark (b. 1744) and Lucey Clark (b. 1750). He studied medicine at Malone, New York, and commenced practice in Canton, NY, in 1822. He was appointed Postmaster of Canton in 1843. In 1845 he was one of four coroners in St. Lawrence County. He was an Inspector of State Prisons from 1850 to 1855, elected on the Democratic ticket in 1849 and 1852, but defeated for re-election on the Hard ticket in 1855.
His testimony at a trial for Manslaughter in the Fourth Degree of a man who had killed a girl with cedar oil when attempting to induce an abortion, in Boston Medical and Surgical Journal issued by the Massachusetts Medical Society and the New England Surgical Society (1849; page 478)