Anspaugh studied at Indiana University and the USC School of Cinematic Arts, after which he taught high school in Colorado. His work as an associate producer on television movies led to his producing and directing Hill Street Blues, for which he won two Emmy Awards. He followed this with St. Elsewhere and Miami Vice before making his feature film debut with Hoosiers. His additional screen credits include Fresh Horses, Rudy, Moonlight and Valentino, and The Game of Their Lives. In spring 2015 Anspaugh taught a class at Indiana University in directing for film and TV. In April 2015 he directed a play for the Bloomington Playwrights Project.
Born in Decatur, Indiana to Lawrence (local photographer) and Marie Anspaugh, he has a younger sister, Jane. He was married from 1974 to 1988 to cruise line sales manager Tamara Kramer. They have a daughter, Vanessa. Anspaugh married actress Roma Downey on November 24, 1995. The couple had a daughter, Reilly Marie, on June 3, 1996. In 1997, Anspaugh was clinically depressed and was treated at a rehabilitation clinic, which ultimately led to a breakdown of his marriage. Downey filed for divorce in March 1998, with it being finalized later that year. After living in California for three decades, in June 2014 Anspaugh relocated to Bloomington, Indiana.
- Walker, George (April 10, 2015). "Ugly Lies the Bone at the BPP". Indiana Public Media. Retrieved April 24, 2015.
- http://pg4anna.tripod.com/weddingpic.htm Della Reese marries Downey/Anspaugh
- http://www.people.com/people/archive/article/0,,20124846,00.html Fall from Grace article in 30 March 98 Vol 49 #12 People (magazine)
- Leonard, Mike (October–November 2014). "Buddies: Filmmakers Angelo Pizzo and David Anspaugh. Back in Bloomington where it all began" (PDF). Bloom magazine. Retrieved April 24, 2015.
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