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David Axelrod may refer to:
- David Axelrod (musician) (1931–2017), American composer, arranger and producer
- David Axelrod (political consultant), (born 1955) senior advisor to former U.S. President Barack Obama.
- David Jason Axelrod Ha'ivri (born 1967), an Israeli settler, political activist
- David Axelrod (physician) (1935–1994), a medical doctor and New York State Commissioner of Health in the 1980s and 1990s; drafted the Libby Zion Law
- David Axelrod, a character from Scott Spencer's novel Endless Love