|Born||8 September 1942
|Alma mater||Harvard University
University of Michigan
|Thesis||The Synthesis and Maturation of Phage-P22 DNA (1967)|
|Doctoral students||Olga Troyanskaya
|Other notable students||Michael Eisen (postdoc)|
|Notable awards||Eli Lilly and Company Award in Microbiology (1978)
Genetics Society of America Medal (1988)
Allan Award of the American Society of Human Genetics (1989)
Gruber Prize in Genetics (2003)
Albany Medical Center Prize (2010)
Breakthrough Prize in Life Sciences (2013)
David Botstein (born 8 September 1942) is an American biologist serving as the Chief Scientific Officer of Calico. He served as the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003–2013, where he remains an Anthony B. Evnin Professor of Genomics.
Botstein graduated from the Bronx High School of Science in 1959, and Harvard University in 1963. He started his Ph.D. work under Maurice Sanford Fox at the Massachusetts Institute of Technology, then moved and received a Ph.D. from the University of Michigan in 1967 for work on P22 phage.
Botstein taught at the Massachusetts Institute of Technology, where he became a Professor of Genetics. Botstein joined Genentech, Inc. in 1987 as Vice President-Science. In 1990, he became Chairman of the Department of Genetics at Stanford University. Dr. Botstein was elected to the U.S. National Academy of Sciences in 1981 and to the Institute of Medicine in 1993.
In 1980, Botstein and his colleagues Ray White, Mark Skolnick, and Ronald W. Davis proposed a method for constructing a genetic linkage map using restriction fragment length polymorphisms that was used in subsequent years to identify several human disease genes including Huntington's and BRCA1. Variations of this method were used in the mapping efforts that predated and enabled the sequencing phase of the Human Genome Project.
In 1998, Botstein and his postdoctoral fellow Michael Eisen, together with graduate student Paul Spellman and colleague Patrick Brown, developed a statistical method and graphical interface that is widely used to interpret genomic data including microarray data. He has subsequently worked on the creation of the influential Gene Ontology with Michael Ashburner and Suzanna Lewis. He is one of the founding editors of the journal Molecular Biology of the Cell, along with Erkki Ruoslahti and Keith Yamamoto.
Botstein has won the Eli Lilly and Company Award in Microbiology (1978), the Genetics Society of America Medal (1988, with Ira Herskowitz), the Allan Award of the American Society of Human Genetics (1989, with Ray White), the Gruber Prize in Genetics (2003) and the Albany Medical Center Prize (2010, with Eric Lander and Francis Collins). In 2013 he was awarded the $3 million Breakthrough Prize in Life Sciences for his work.
- Mullins, J.; Morrison Mckay, B. (2011). "International Society for Computational Biology Honors Michael Ashburner and Olga Troyanskaya with Top Bioinformatics/Computational Biology Awards for 2011". PLoS Computational Biology 7 (6): e1002081. doi:10.1371/journal.pcbi.1002081. PMC 3107244.
- Mahowald, A. (1988). "Genetics society of america records, proceedings and reports". Genetics 119 (2): s1–s15. PMC 1203430. PMID 17246435.
- http://www.molbio2.princeton.edu/index.php?option=content&task=view&id=201 David Botstein at Princeton Department of Molecular Biology
- http://www.princeton.edu/genomics/botstein/ Botstein Laboratory Princeton
- Gitschier, J. (2006). "Willing to Do the Math: An Interview with David Botstein". PLoS Genetics 2 (5): e79. doi:10.1371/journal.pgen.0020079. PMC 1464829. PMID 16733551.
- http://www.dailyprincetonian.com/archives/2005/10/18/news/13503.shtml The Daily Princetonian - Mapping the path of genetics
- Botstein, David (1967). The Synthesis and Maturation of Phage-P22 DNA (PhD thesis). University of Michigan.
- Thean, Tara. "Integrated Science Pays Off for Graduates". The Daily Princetonian. Princeton University Press. Retrieved 23 October 2011.
- Botstein, D.; White, R.; Skolnick, M.; Davis, R. (1980). "Construction of a genetic linkage map in man using restriction fragment length polymorphisms". American Journal of Human Genetics 32 (3): 314–331. PMC 1686077. PMID 6247908.
- Eisen, M.; Spellman, P.; Brown, P.; Botstein, D. (1998). "Cluster analysis and display of genome-wide expression patterns". Proceedings of the National Academy of Sciences of the United States of America 95 (25): 14863–14868. doi:10.1073/pnas.95.25.14863. PMC 24541. PMID 9843981.
- Botstein, D.; Cherry, J. M.; Ashburner, M.; Ball, C. A.; Blake, J. A.; Butler, H.; Davis, A. P.; Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis, A.; Lewis, S.; Matese, J. C.; Richardson, J. E.; Ringwald, M.; Rubin, G. M.; Sherlock, G. (2000). "Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium". Nature Genetics 25 (1): 25–29. doi:10.1038/75556. PMC 3037419. PMID 10802651.
- "MBC Editorial Board".
- David Botstein's talk: "An Integrated Science Curriculum"
- David Botstein iBiology Seminar: "Fruits of the Genome Sequence"
Lewis-Sigler Institute for Integrative Genomics