|Date of birth:||January 28, 1984|
|Place of birth:||Plano, Texas|
|Height:||6 ft 4 in (1.93 m)|
|Weight:||220 lb (100 kg)|
|* Offseason and/or practice squad member only|
|Career CFL statistics|
He began play for the Stanford Cardinal football team in 2002 as a true freshman quarterback and did not play. In the spring of 2003, he converted to the wide receiver position but saw limited playing time though he did catch two balls for 10 yards in the season finale.
Lofton played in all 11 games of the 2005 Cardinals season including five weeks as the starting free safety, finishing the year with 35 total tackles and one tackle-for-loss. He started six games and played the first seven of the 2006 season with a stress fracture in his foot before suffering a season-ending fracture that caused him to miss the final five games. He finished the year seventh on the team with 47 total tackles.
Lofton then signed with the Hamilton Tiger-Cats of the Canadian Football League as a free agent on September 12 and dressed for four games (four starts) of the 2007 CFL season making 17 defensive tackles, 1 special teams tackle, and 1 quarterback sack. He was released following off-season surgery.
The Toronto Argonauts signed Lofton as a free agent on September 23 of the 2008 Toronto Argonauts season and placed him on the practice squad for week 13 before deferring his contract on September 29. He was re-signed on March 25, 2009. He was released on May 12, 2009.
New York Sentinels
Lofton is the son of former NFL Hall of Fame wide receiver James Lofton. James Lofton coached five seasons in San Diego with then-offensive coordinator Cam Cameron, who originally signed David Lofton out of college in 2007. The elder Lofton also attended Stanford, from 1974 to 1977. David Lofton gave his father's Pro Football Hall of Fame induction speech in 2003.
- "David Lofton". Roster. Toronto Argonauts Football Club. Retrieved 2009-03-25.
- "Argonauts sign import OL Afif". TSN.ca. 2009-03-25. Retrieved 2009-03-25.