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She has covered various stories, including extensive coverage of the 9/11 attacks and the War in Iraq. She reported from New York City and Europe, including in-depth reports from London on Prime Minister Tony Blair's critical decision to support the U.S. on Iraq.
Before joining Dateline, Fratangelo was a general assignment correspondent for NBC based in Chicago, a position she held since April 1993. She covered stories of national interest from the Midwest floods and California wildfires, as well as child custody and welfare issues.
She received her undergraduate education at SUNY Plattsburgh (in Plattsburgh, New York) and began her career there as a news anchor at WPTZ from 1983 to 1985. In 1985, she worked at KFMB-TV as a newscaster and reporter. She joined WCVB-TV in 1986 to hold the same position, but left in 1991 to co-anchor the 6pm edition of News 4 New York with Chuck Scarborough on WNBC until 1993.
Fratangelo was divorced from her first husband in the early 1990s. In 1997, she married Eric Wishnie, a producer for NBC News. By 2006, Fratangelo and Wishnie had separated; he committed suicide in 2007.