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De Smet or Desmet may refer to:
- De Smet, South Dakota, a town in Kingsbury County, South Dakota, United States
- De Smet, Idaho, a town in Benewah County, Idaho, United States
- De Smet, an unincorporated community in Missoula County, Montana, United States
- Desmet method, a method for restoring the colours of early silent films
- De Smet Jesuit High School, Creve Coeur, Missouri, United States
| disambiguation page lists articles associated with the title De Smet.
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