De novo

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In general usage, de novo (literally 'of new') is Latin expression used in English to mean 'from the beginning', 'anew'.

De novo may also refer to:


  • De novo, mutation, an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself
  • De novo, protein design, the creation of a protein sequence that is not based on existing, natural sequences
  • De novo protein structure prediction, the prediction of a protein's 3D structure, based only on its sequence
  • De novo synthesis of complex molecules from simple molecules in chemistry
  • De novo transcriptome assembly, the method of creating a transcriptome without a reference genome
  • De novo gene birth, the emergence of genes from non-coding sequence
  • De novo methods, Genomics,The de novo computational methods only use genomic data to explore nonrandom mutually exclusive patterns (Deng et al 2019 Briefings in Bioinformatics)