De novo synthesis

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De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to recycling after partial degradation. For example, nucleotides are not needed in the diet as they can be constructed from small precursor molecules such as formate and aspartate. Methionine, on the other hand, is needed in the diet because while it can be degraded to and then regenerated from homocysteine, it cannot be synthesized de novo.

De novo is a Latin phrase, literally translating to "from the new", but implying "anew", "from scratch", or "from the beginning."

De novo nucleotide synthesis[edit]

De novo pathways of nucleotides do not use free bases: adenine (abbreviated as A), guanine (G), cytosine (C), thymine (T), or uracil (U). The purine ring is built up one atom or a few atoms at a time and attached to ribose throughout the process. Pyrimidine ring is synthesized as orotate and attached to ribose phosphate and later converted to common pyrimidine nucleotides.

De novo cholesterol synthesis[edit]

De novo cholesterol synthesis is a pathway used by the Schwann cells to promote cell motility and viability.

De novo fatty acid synthesis[edit]

De novo DNA synthesis[edit]

De novo DNA synthesis is DNA replication without the need for precursor template DNA. It's also referred to as artificial gene synthesis. Primase is an RNA polymerase, and it can add a primer to an existing strand awaiting replication. DNA polymerase cannot add primers, and therefore, needs primase to add the primer de novo.


Harper's Illustrated Biochemistry, 26th Ed - Robert K. Murray, Darryl K. Granner, Peter A. Mayes, Victor W. Rodwell

Lehninger Principles of Biochemistry, Fourth Edition - David L. Nelson, Michael M. Cox Biochemistry 5th ed - Jeremy M. Berg, John L. Tymoczko, Lubert Stryer Biochemistry- Garrett.and.Grisham.2nd.ed Biochemistry, 2/e by Reiginald and Charles Grisham Biochemistry for dummies by John T Moore, EdD and Richard Langley, PhD Stryer L (2007). Biochemistry. 6th Edition. WH Freeman and Company. New York. USA

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