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Dead space may refer to:
- Dead space (physiology), air that is inhaled but does not play a role in gas exchange
- Dead space ventilation, air exchange
- Deadspace in breathing apparatus, excess space which the flow of air or breathing gas must pass through and back again as the user breathes in and out, increasing the necessary respiratory effort to get the same amount of usable air or breathing gas (see Dead space (physiology)#In breathing apparatus).
Video game and media franchise
- Dead Space (series), a series of third-person survival horror video games
- Dead Space (2011 video game), a 2011 third-person survival horror for mobile devices
- Dead Space (comics), a 2008 comic book prequel
- Dead Space (film), a 1991 science-fiction film
- Dead Space (album), a 1994 album by Slowdown Virginia
- Dead Space Recording, a recording studio in Lincoln, Nebraska
- Dead Space, an excess space when using non-identical displays in Xinerama
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