Debrisoquine

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Debrisoquine[1]
Debrisoquine.svg
Names
IUPAC name
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
Identifiers
3D model (Jmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.013.155
KEGG
MeSH Debrisoquine
UNII
Properties
C10H13N3
Molar mass 175.23032
Pharmacology
C02CC04 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug metabolizing enzyme.[2]

See also[edit]

The guanidine part of the molecule also appears in guanoxan and guanadrel.

  • The 7-bromo analog of Debrisoquine is called Guanisoquin.

References[edit]

  1. ^ Debrisoquine – Compound Summary, PubChem.
  2. ^ Fuhr, U.; Jetter, A.; Kirchheiner, J. (2007). "Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach". Clinical Pharmacology & Therapeutics. 81 (2): 270–283. doi:10.1038/sj.clpt.6100050.