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Diagrammatic sections of the uterine mucous membrane: A. The non-pregnant uterus. B. Decidua parietalis; the mucous membrane in the pregnant uterus and not beneath the placenta.
Sectional plan of the gravid uterus in the third and fourth month
The decidua is the modified mucosal lining of the uterus (that is, modified endometrium) that forms in preparation for pregnancy. It is formed in a process called decidualization under the influence of progesterone. Endometrial cells become highly characteristic. The decidua forms the maternal part of the placenta and remains for the duration of the pregnancy. It is shed off during childbirth — hence why the term is used, "decidua" having the meaning of falling away, as in the word deciduous.
The part of the decidua that interacts with the trophoblast is the decidua basalis (also called decidua placentalis), while the decidua capsularis grows over the embryo on the lumenal side, enclosing it into the endometrium. The remainder of the decidua is termed the decidua parietalis or decidua vera, and it will fuse with the decidua capsularis by the fourth month of gestation.
Three morphologically distinct layers of the decidua basalis can then be described:
- Compact outer layer (stratum compactum)
- Intermediate layer (stratum spongiosum)
- Boundary layer adjacent to the myometrium (stratum basalis)
Within the decidua, occasional fibrinoid deposits form where the syncytiotrophoblast is damaged. The region of fibrinoid deposition where trophoblasts meet the compact portion of the decidua basalis is called Rohr's layer, while the fibrinoid deposits that occur between the compact and spongy layer of the decidua basalis is termed Nitabuch's layer. This layer is absent in placenta accreta.
The decidua has a histologically-distinct appearance, displaying large polygonal decidual cells in the stroma. These are enlarged endometrial stromal cells, which resemble epithelium (and are referred to as "epithelioid").
Decidualization includes the process of differentiation of the spindle-shape stromal fibroblasts into the plump secretory decidual cells, which create a pericellular extracellular matrix rich in fibronectin and laminin (similar to epithelial cells).
Vascularity, as well as vascular permeability, is enhanced in the decidualizing endometrium.
In animals exhibiting hemochorial placentation, the endometrium undergoes decidualization following implantation. If implantation does not occur, the secretory lining will be absorbed (estrous cycle) or shed (menstrual cycle).
The decidua is shed with the placenta during birth.
As the maternal interface to the embryo the decidua participates in the exchanges of nutrition, gas, and waste with the gestation. It also protects the pregnancy from the maternal immune system. Further, the decidua has to allow a very controlled invasion of the trophoblast.
In invasive placental disorders like placenta accreta decidualization have been consistently found to be deficient.
- In case of an extrauterine pregnancy, the endometrium nevertheless becomes decidualized. A woman may shed the lining in the form of a decidual cast, which may be mistaken as a miscarriage, when, in fact, the ectopic pregnancy still persists.
- A decidual reaction can be observed in tissue of the peritoneum and ovary during a pregnancy, and represents a response of stromal tissue to progesterone.
- Decidua in a lymph node may mimic metastatic carcinoma.
The word comes from Latin deciduus, meaning 'falling off / shedding'.
- Cunningham, F. Gary, ed. (2005). Williams obstetrics (22nd ed.). New York; Toronto: McGraw-Hill Professional. ISBN 9780071413152.
- Wu, DC.; Hirschowitz, S.; Natarajan, S. (May 2005). "Ectopic decidua of pelvic lymph nodes: a potential diagnostic pitfall". Arch Pathol Lab Med. 129 (5): e117–20. doi:10.1043/1543-2165(2005)129<E117:EDOPLN>2.0.CO;2 (inactive 2020-01-22). PMID 15859655.
- Edmondson, N.; Bocking, A.; Machin, G.; Rizek, R.; Watson, C.; Keating, S. (2009). "The prevalence of chronic deciduitis in cases of preterm labor without clinical chorioamnionitis". Pediatr Dev Pathol. 12 (1): 16–21. doi:10.2350/07-04-0270.1. PMID 18171100.