Deep South Wrestling held their inaugural show on September 1, 2005. Two months later, the promotion crowned Mike Mizanin as their first Deep South Heavyweight Champion. The promotion gained a timeslot on Comcast Sports South on Sunday nights at 11:30 p.m.
On April 18, 2007, WWE announced that they were ending its relationship with Deep South. Deep South confirmed the cancellation of their April 19, 2007 television taping on their website. The closure of the promotion was announced on Deep South's website on April 19, although Deep South held its final event on April 12. Because of Deep South parting ways, talent not under WWE developmental contracts left the promotion. Those that remained under contract were reassigned to Ohio Valley Wrestling.
On April 30, 2009, it was announced to the wrestling media that Hamilton, under the DSW banner, had filed a lawsuit against WWE. The suit claims WWE committed breach of contract and intentional interference with contractual and business relations. The suit was filed on April 20 and is pending in Fulton County, Georgia.