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Deep dermatophytosis is a rare condition in which dermatophytes invades the deep dermis, subcutis or even internal organs. The known causes of this condition are caused by primary or secondary immunodeficiency, which includes organ tranplant recipients, maglignant conditionds e.g. leukemia, HIV infection. It is also associated with Asthma, atopic dermatitis and Diabetes.
Recently it has been proven that deficiency in the NF-κB signaling pathways, The nonsense mutation of CARD9-complex (Caspase recruitment domain-containing protein 9), are susceptible for chronic fungal infection. Thus also susceptible for Deep Dermatophytosis.
- 1 Chastain MA, et al. Deep dermatophytosis: report of 2 cases and review of the literature. Cutis 2001;67:457
- 2 Hay RJ, Baran R. Deep dermatophytosis: rare infections or common, but unrecognized, complications of lymphatic spread? Curr Opin Infect Dis 2004;17:77
- 3 Glocker EO, et al. A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections N Engl J Med. 2009 October 29; 361(18): 1727–1735.
- 4 Lanternier F., et al. Deep dermatophytosis and inherited CARD9 deficiency. N Engl J Med. 2013 Oct 31;369(18):1704-14.
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