Delapril

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Delapril
Delapril.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C26H32N2O5
Molar mass 452.542 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15mg and 30mg tablets.[3]

Mechanism[edit]

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]

References[edit]

  1. ^ Otero, M. L. (2007). "Manidipine-delapril combination in the management of hypertension". Vascular health and risk management. 3 (3): 255–263. PMC 2293964Freely accessible. PMID 17703633. 
  2. ^ Drugs.com: Delapril
  3. ^ "http://cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY". cursoenarm.net. Retrieved 2016-08-28.  External link in |title= (help)
  4. ^ Pubchem. "DELAPRIL | C26H32N2O5 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2016-08-28.