Delta-like 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DLL1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1
External IDs MGI: 104659 HomoloGene: 4104 GeneCards: DLL1
RNA expression pattern
PBB GE DLL1 gnf1h00074 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005618

NM_007865

RefSeq (protein)

NP_005609

NP_031891.2
NP_031891

Location (UCSC) Chr 6: 170.28 – 170.31 Mb Chr 17: 15.37 – 15.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[3]

Function[edit]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[3]

Interactions[edit]

Delta-like 1 has been shown to interact with NOTCH2[4][5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: DLL1 delta-like 1 (Drosophila)". 
  4. ^ Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656. 
  5. ^ Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. 
  6. ^ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767Freely accessible. PMID 10958687. 

Further reading[edit]