Demecarium bromide

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Demecarium bromide
Demecarium bromide.svg
Clinical data
Trade namesHumorsol
Routes of
Topical (ophthalmic solution)
ATC code
CAS Number
PubChem CID
ECHA InfoCard100.000.274 Edit this at Wikidata
Chemical and physical data
Molar mass716.588 g/mol g·mol−1
3D model (JSmol)
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Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1]

Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other inhibitors, such as carbachol.[3]

Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[4] is no longer available,[3] although solutions of demecarium can be compounded.[5]

Use in dogs[edit]

When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[3]

See also[edit]


  1. ^ Jeske, Arthur H., ed. (2014). "Demecarium bromide". Mosby's dental drug reference (11th ed.). St. Louis, Missouri: Elsevier Mosby. p. 374. ISBN 978-0-323-16916-5.
  2. ^ Stein, Harold A.; Stein, Raymond M.; Freeman, Melvin I. (2012). Ophthalmic dictionary and vocabulary builder for eye care professionals (4th ed.). New Delhi: Jaypee Brothers Medical. p. 103. ISBN 9789350253656.
  3. ^ a b c d Maggs, David J.; Miller, Paul E.; Ofri, Ron (2013). "Indirect-acting parasympathomimetic agents". Slatter's Fundamentals of Veterinary Ophthalmology (5th ed.). St. Louis, Missouri: Elsevier. p. 51. ISBN 978-1-4377-2367-0.
  4. ^ Edmunds, Marilyn Winterton; Mayhew, Maren Stewart (2013). Pharmacology for the primary care provider (4th ed.). Elsevier Health Sciences. p. 174. ISBN 978-0-323-08790-2.
  5. ^ Alario, AF; Strong, TD; Pizzirani, S (November 2015). "Medical treatment of primary canine glaucoma". The Veterinary clinics of North America. Small animal practice. 45 (6): 1235–59, vi. doi:10.1016/j.cvsm.2015.06.004. PMID 26319445.