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Denise Ann Darvall (27 February 1942 – 3 December 1967) was the donor in the world’s first successful human heart transplant, performed at Groote Schuur Hospital, South Africa, by a team of surgeons led by Christiaan Barnard.
Darvall was seriously injured in a car accident on Main Road in Observatory, Cape Town. She and her family were visiting friends for afternoon tea and went shopping for cake. She and her mother were run over by a driver who failed to see them, due to a large truck that obscured his vision of them, and their vision of his car. Her mother died immediately. Darvall sustained a skull fracture and severe head injuries, after the car flung her across the road and her head hit the wheel cap of her own car. She could not stay alive without life support, and was essentially brain dead. At 9 p.m. on the day of the accident, the resuscitation team stopped trying to revive her.
Father gives permission
Edward Darvall arranged for his fourteen-year son, who had witnessed the accident, to be taken away from the hospital. The 66-year-old Edward was also given a sedative, and he waited while doctors attempted to save his daughter. Two doctors, Coert Venter and Bertie Bosman, informed him that there was nothing further they could do for Denise. Bosman explained that there was a man in the hospital they might be able to help, and asked Edward if he would consider allowing them to transplant Denise's heart.
Edward Darvall later said that he thought only of his daughter in the four minutes it took him to reach his decision, and gave his permission.
Declaration of death
Surgeons had a serious ethical problem because death then could only be declared by whole-body standards. The Harvard Criteria of Brain Death was not developed until 1968, nor was it adopted in South Africa or elsewhere for some years. The problem in this case was that, although Denise's brain was damaged, her heart was healthy. Various reports over the years attributed conflicting reasons for her heart stopping. For forty years, Barnard's brother Marius kept a secret: that rather than wait for her heart to stop beating, at Marius’s urging, Christiaan had injected potassium into Denise’s heart to paralyze it and thus, to render her technically dead by the whole-body standard.
After her father gave his consent, Darvall's heart was donated to Louis Washkansky. Her kidneys were given to 10-year-old Jonathan van Wyk. Due to apartheid, the kidney donation to Van Wyk was controversial because he was black, while Denise was white. Washkansky would only live for another 18 days, succumbing to pneumonia.
- ancestry42 Archived 17 January 2013 at Archive.is
- Every Second Counts: The Race to Transplant the First Human Heart, Donald McRae, New York: Putnam, 2006, page 189.
- Every Second Counts, McRae, page 192.
- Malan, M. "Darvall, Denise". sahistory.org. South Africa History. Retrieved 30 May 2015.
- Christiaan Barnard and Curtiss Bill Pepper, "One Life," MacMillan, New York, 1969.
- Christiaan Barnard, "The Second Life," Vlaeberg Publishers, South Africa, 1993.