Dennis S. Charney

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Dennis S. Charney
Dennis S. Charney, MD.jpg
Dennis S. Charney, M.D.
Nationality American
Fields Biological psychiatry
Institutions Icahn School of Medicine at Mount Sinai
Alma mater Penn State, Yale School of Medicine

Dennis S. Charney is an American biological psychiatrist and researcher, one of the world's leading experts in the neurobiology and treatment of mood and anxiety disorders.[1] He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular Biology for the Clinician, as well as the author of over 500 original papers and chapters.

He is a Professor of Psychiatry, Professor of Neuroscience and Professor of Pharmacology and Systems Therapeutics at Icahn School of Medicine at Mount Sinai in New York City, and currently Dean of the school.


Charney graduated from medical school at Penn State in 1977 and completed his residency in Psychiatry at Yale School of Medicine. A fellowship in Biological Psychiatry was completed at the Connecticut Medical Health Center.

Charney became the Dean of Research at Mount Sinai School of Medicine in 2004, later becoming the Dean for Academic and Scientific Affairs, finally succeeding Kenneth L. Davis as Dean of the school in 2007.[2]

He has been named among the top 3 most highly cited authors of psychiatric research in the decade ending in 2000 by the Institute for Scientific Information, and listed in every edition of the “Best Doctors in America” since 1992.[3]

He owns patents in dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia[4] and in intranasal administration of ketamine to treat depression.[5]

He was elected to the Institute of Medicine in 2000.[6]

Charney was shot and wounded as he left a deli in his home town of Chappaqua, New York, early on the morning of August 29, 2016. Hengjun Chao, a former Mount Sinai faculty member who had been fired for cause in 2010, was arrested and charged with attempted murder.[7][8] As reported by Jonah Bromwich in the New York Times, "A former faculty member at the Mount Sinai School of Medicine who had been fired shot the school’s dean outside a popular deli in Chappaqua, N.Y., on Monday, apparently in an act of revenge, the authorities said... Mount Sinai officials confirmed that the dean, Dr. Dennis S. Charney, 65, of Chappaqua, was one of the victims. The name of the other victim was not released. This is an extremely disturbing event,' Dr. Kenneth L. Davis, the chief executive of the Mount Sinai Health System, said in a statement. 'Fortunately, Dr. Charney’s injuries are not life-threatening, and we expect he will fully recover.'"[9]

Affiliations and positions[edit]

Awards and honors[edit]

  • Efron Award from the American College of Neuropsychopharmacology [13]
  • Anna Monika Foundation Award for Research in Affective Disorders [14]
  • The Edward J. Sacher Award from Columbia University
  • The Edward A. Strecker Award from Pennsylvania Hospital and the University of Pennsylvania [15]
  • The Gerald L. Klerman Lifetime Achievement Award from the Depression and Bipolar Support Alliance (DBSA)
  • The Heinz Lehman Award from the New York State Department of Mental Health
  • The American Psychiatric Association Award for Research
  • The American College of Psychiatrists Award for Depression Research
  • The Gold Medal Award from the Society of Biological Psychiatry[16]
  • Distinguished Alumni Award from the Pennsylvania State University School of Medicine [17]
  • The 2004 CINP-Lilly Neuroscience Clinical Research Award

Books and publications (partial list)[edit]


  • Stress-induced and Fear Circuitry Disorders: Refining the Research Agenda for Dsm-v by Gavin Andrews, Dennis S. Charney, Paul J. Sirovatka, Darrel A. Regier, American Psychiatric Publishing, ISBN 0-89042-344-X
  • Molecular Biology for the Clinician, by Dennis S. Charney, American Psychiatric Press, ISBN 978-1-58562-113-2
  • The Physician's Guide to Depression & Bipolar Disorders by Dennis S. Charney, Lydia Lewis, McGraw-Hill, ISBN 0-07-144175-1 (0-07-144175-1)
  • Neurobiology of Mental Illness by Eric J. Nestler, Dennis S. Charney, Oxford Press, ISBN 0-19-518980-9 (0-19-518980-9)
  • Pediatric Psychoparmacology: Principles and Practice by James F. Leckman, Dennis S. Charney, Lawrence Scahill, Andres Martin, Oxford Univ Pr, ISBN 0-19-514173-3 (0-19-514173-3)
  • Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder by Matthew J. Friedman, Dennis S. Charney, Ariel Y. Deutch, Lippincott Williams & Wilkins, ISBN 0-7817-0177-5 (0-7817-0177-5)
  • Neuropsychopharmacology: The Fifth Generation of Progress by American College of Neuropsychopharmacology and Joseph T. Coyle and Charles Nemeroff and Dennis Charney and Kenneth L. Davis, Hardcover, Lippincott Williams & Wilkins, ISBN 0-7817-2837-1 (0-7817-2837-1)


  • Trauma and Resilience in the Third Year of Medical School: A Prospective Study of the Effects of Clinical Rotations on Student Well-being. Haglund M, aan het Rot M, Cooper N, Muller D, Southwick SM, Charney DS. Academic Medicine, February 2009; 84(2):258-68. doi:10.1097/ACM.0b013e31819381b1 PMID 19174682
  • Enduring mental health morbidity and social function impairment in world trade center rescue, recovery, and cleanup workers: the psychological dimension of an environmental health disaster. Stellman JM, Smith RP, Katz CL, Sharma V, Charney DS, Herbert R, Moline J, Luft BJ, Markowitz S, Udasin I, Harrison D, Baron S, Landrigan PJ, Levin SM, Southwick S. Environ Health Perspect, 2008 doi:10.1289/ehp.11164 PMID 18795171
  • Novel drugs and therapeutic targets for severe mood disorders. Mathew SJ, Manji HK, Charney DS. Neuropsychopharmacology. 2008 Aug;33(9):2080. Epub 2008 Jun 4. PMID 18172433
  • Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist. Horn TL, Harder JB, Johnson WD, Curry PT, Parchment RE, Morrissey RL, Mellick PW, Calis KA, Gold PW, Rice KC, Contoreggi C, Charney DS, Cizza G, Glaze ER, Tomaszewski JE, McCormick DL. Toxicology. 2008 Jun 3;248(1):8-17. Epub 2008 Mar 13. doi:10.1016/j.tox.2008.03.002 PMID 18423834
  • Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Mathew SJ, Price RB, Charney DS. Am J Med Genet C Semin Med Genet. 2008 May 15;148(2):89-98. doi:10.1002/ajmg.c.30172 PMID 18412102
  • Response to Emotional Expressions in Generalized Social Phobia and Generalized Anxiety Disorder: Evidence for Separate Disorders. Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Mondillo K, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS. American Journal of Psychiatry. 2008 May 15. doi:10.1176/appi.ajp.2008.07071060 PMID 18483136
  • Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder. Mathew SJ, Price RB, Mao X, Smith EL, Coplan JD, Charney DS, Shungu DC. Biological Psychiatry. 2008 May 1;63(9):891-8. doi:10.1016/j.biopsych.2007.09.012 PMID 18028881
  • Association between level of emotional intelligence and severity of anxiety in generalized social phobia. Jacobs M, Snow J, Geraci M, Vythilingam M, Blair RJ, Charney DS, Pine DS, Blair KS. Journal of Anxiety Disorder. 2008 Mar 13. doi:10.1016/j.janxdis.2008.03.003 PMID 18439799
  • Mental health of workers and volunteers responding to events of 9/11: review of the literature. Bills CB, Levy NA, Sharma V, Charney DS, Herbert R, Moline J, Katz CL. doi:10.1002/msj.20026 PMID 18500712
  • Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression. Czermak C, Hauger R, Drevets WC, Luckenbaugh DA, Geraci M, Charney DS, Neumeister A. Journal of Affective Disorder. 2008 Feb 15. doi:10.1016/j.jad.2008.01.014 PMID 18281099
  • Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Masten CL, Guyer AE, Hodgdon HB, McClure EB, Charney DS, Ernst M, Kaufman J, Pine DS, Monk CS. Child Abuse Negl. 2008 Jan;32(1):139-53. Epub 2007 Dec 21. doi:10.1016/j.chiabu.2007.09.006 PMID 18155144
  • Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. Biological Psychiatry. 2007 Oct 15;62(8):870-7. Epub 2007 Aug 2. doi:10.1016/j.biopsych.2007.03.016 PMID 17678634
  • Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A. Kling MA, Alesci S, Csako G, Costello R, Luckenbaugh DA, Bonne O, Duncko R, Drevets WC, Manji HK, Charney DS, Gold PW, Neumeister A. Biological Psychiatry. 2007 Aug 15;62(4):309-13. doi:10.1016/j.biopsych.2006.09.033 PMID 17178112
  • Diagnosing bipolar disorder in trauma exposed primary care patients. Graves RE, Alim TN, Aigbogun N, Chrishon K, Mellman TA, Charney DS, Lawson WB. Bipolar Disorder. 2007 Jun;9(4):318-23. doi:10.1111/j.1399-5618.2007.00449.x PMID 17547578
  • Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Nemeroff CB, Kalali A, Keller MB, Charney DS, Lenderts SE, Cascade EF, Stephenson H, Schatzberg AF. Arch Gen Psychiatry. 2007 Apr;64(4):466-72. doi:10.1001/archpsyc.64.4.466 PMID 17404123
  • Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ, Fromm S, Charney DS, Leibenluft E, Ernst M, Pine DS. Arch Gen Psychiatry. 2007 Jan;64(1):97-106. doi:10.1001/archpsyc.64.1.97 PMID 17199059


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