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Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
Oral (tablets)
ATC code
  • none
Legal status
Legal status
  • ℞-only (JP)
CAS Number
PubChem CID
ECHA InfoCard100.163.233 Edit this at Wikidata
Chemical and physical data
Molar mass317.37 g/mol g·mol−1
3D model (JSmol)

Denopamine (INN) is a cardiotonic drug which acts as a β1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.[5]


  1. ^ Ishide, T (2002). "Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator". Curr Med Res Opin. 18 (7): 407–13. doi:10.1185/030079902125001119. PMID 12487507.
  2. ^ Nakajima, D; Negoro, N; Nakaboh, A; Nakakoji, T; Hoshiga, M; Nariyama, J; Ishihara, T; Hanafusa, T (Apr 2006). "Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment". International Journal of Cardiology. 108 (2): 281–3. doi:10.1016/j.ijcard.2005.03.012. PMID 15913812.
  3. ^ Nishio, R; Matsumori, A; Shioi, T; Wang, W; Yamada, T; Ono, K; Sasayama, S (Sep 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". Journal of the American College of Cardiology. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. PMID 9741531.
  4. ^ Sakuma, T; Hida, M; Nambu, Y; Osanai, K; Toga, H; Takahashi, K; Ohya, N; Inoue, M; Watanabe, Y (Feb 2001). "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Japanese Journal of Pharmacology. 85 (2): 161–6. doi:10.1254/jjp.85.161. PMID 11286398.
  5. ^ "Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information" (PDF) (in Japanese). Mitsubishi Tanabe Pharma Corporation. Retrieved 6 March 2016.