Deoxycytidine kinase

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DCK
Protein DCK PDB 1p5z.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DCK, entrez:1633
External IDs OMIM: 125450 MGI: 102726 HomoloGene: 616 GeneCards: 1633
RNA expression pattern
PBB GE DCK 203302 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000788

NM_007832

RefSeq (protein)

NP_000779.1

NP_031858.1

Location (UCSC) Chr 4: 70.99 – 71.03 Mb Chr 5: 88.76 – 88.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Deoxycytidine kinase, also known as DCK, is an enzyme which in humans is encoded by the DCK gene.[1]

DCK transfers phosphate to deoxycytidine.

Function[edit]

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.[1]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]