Deoxycytidine kinase

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Deoxycytidine kinase
Protein DCK PDB 1p5z.png
PDB rendering based on 1p5z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DCK ; MGC117410; MGC138632
External IDs OMIM125450 MGI102726 HomoloGene616 ChEMBL: 2447 GeneCards: DCK Gene
EC number
RNA expression pattern
PBB GE DCK 203302 at tn.png
More reference expression data
Species Human Mouse
Entrez 1633 13178
Ensembl ENSG00000156136 ENSMUSG00000029366
UniProt P27707 P43346
RefSeq (mRNA) NM_000788 NM_007832
RefSeq (protein) NP_000779 NP_031858
Location (UCSC) Chr 4:
70.99 – 71.03 Mb
Chr 5:
88.76 – 88.78 Mb
PubMed search [1] [2]

Deoxycytidine kinase, also known as DCK, is an enzyme which in humans is encoded by the DCK gene.[1]

DCK transfers phosphate to deoxycytidine.


Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.[1]

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