Deoxycytidylate 5-hydroxymethyltransferase

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deoxycytidylate 5-hydroxymethyltransferase
EC no.
CAS no.9012-68-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a deoxycytidylate 5-hydroxymethyltransferase (EC is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, H2O, and deoxycytidylate, whereas its two products are tetrahydrofolate and 5-hydroxymethyldeoxycytidylate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase. Other names in common use include dCMP hydroxymethylase, d-cytidine 5'-monophosphate hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, and deoxycytidylic hydroxymethylase. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1B49, 1B5D, and 1B5E.


  • Mathews CK, Brown F, Cohen SS (1964). "Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase". J. Biol. Chem. 239: 2957–2963. PMID 14217882.