Deoxyribonuclease II

From Wikipedia, the free encyclopedia
Jump to: navigation, search
deoxyribonuclease II alpha
Symbol DNASE2
Alt. symbols DNASE2A, DRN2, DNL, DNL2
Entrez 1777
HUGO 2960
OMIM 126350
RefSeq NM_001375
UniProt O00115
Other data
EC number
Locus Chr. 19 p13.2
deoxyribonuclease II beta
Symbol DNASE2B
Entrez 58511
HUGO 28875
OMIM 608057
RefSeq NM_021233
UniProt Q8WZ79
Other data
EC number
Locus Chr. 1 p22.3

Deoxyribonuclease II (EC, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.

There are several known DNases II, including:

  • DNase II alpha (usually known as DNase II), which is thought to be ubiquitously expressed in human tissue[1]
  • DNase II beta (also called DLAD, or DNase II-Like Acid DNase), which is mainly expressed in the eye lens and salivary glands. Low levels have also been detected in the lung, prostate and lymph nodes.[2]


  1. ^ Yasuda T, Takeshita H, Iida R, Tsutsumi S, Nakajima T, Hosomi O, Nakashima Y, Mori S, Kishi K (July 1998). "Structure and organization of the human deoxyribonuclease II (DNase II) gene". Annals of Human Genetics. 62 (Pt 4): 299–305. doi:10.1046/j.1469-1809.1998.6240299.x. PMID 9924608. 
  2. ^ Universal protein resource accession number Q8WZ79 for "DNASE2B - Deoxyribonuclease-2-beta precursor - Homo sapiens (Human) - DNASE2B gene & protein" at UniProt.

External links[edit]