Deoxyribonuclease II (EC188.8.131.52, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acidpH.
DNase II alpha (usually known as DNase II), which is thought to be ubiquitously expressed in human tissue
DNase II beta (also called DLAD, or DNase II-Like Acid DNase), which is mainly expressed in the eye lens and salivary glands. Low levels have also been detected in the lung, prostate and lymph nodes.
^Yasuda T, Takeshita H, Iida R, Tsutsumi S, Nakajima T, Hosomi O, Nakashima Y, Mori S, Kishi K (July 1998). "Structure and organization of the human deoxyribonuclease II (DNase II) gene". Annals of Human Genetics. 62 (Pt 4): 299–305. doi:10.1046/j.1469-1809.1998.6240299.x. PMID9924608.
^Universal protein resource accession number Q8WZ79 for "DNASE2B - Deoxyribonuclease-2-beta precursor - Homo sapiens (Human) - DNASE2B gene & protein" at UniProt.