Deoxyribonuclease ii, lysosomal

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DNASE2
Identifiers
AliasesDNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal
External IDsMGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for DNASE2
Genomic location for DNASE2
Band19p13.13Start12,875,211 bp[1]
End12,881,468 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001375

NM_010062

RefSeq (protein)

NP_001366
NP_001366.1

NP_034192

Location (UCSC)Chr 19: 12.88 – 12.88 MbChr 8: 84.91 – 84.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. [5]

Function[edit]

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003812 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.

Further reading[edit]

  • Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.